⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218162 | 0.78 | FFAR3 (0.32) | — | |
| SCHEMBL5211649 | 0.76 | TSHR (0.35) | — | |
| SCHEMBL3809509 | 0.72 | FFAR3 (0.38) | — | |
| SCHEMBL2006692 | 0.71 | CYP2C19 (0.35) | — | |
| SCHEMBL5509879 | 0.70 | CYP2C19 (0.38) | — | |
| SCHEMBL5513287 | 0.70 | CYP2C19 (0.38) | — | |
| SCHEMBL2862907 | 0.70 | CYP2C19 (0.38) | — | |
| SCHEMBL14420982 | 0.70 | FFAR3 (0.42) | — | |
| SCHEMBL11301399 | 0.70 | CYP2C19 (0.38) | — | |
| SCHEMBL14037335 | 0.69 | FFAR3 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | claimed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | claimed |
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |