Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 0.81 |
| ▸ | HTR1B | P28222 | 20/20 | 0.81 |
| ▸ | HTR1A | P08908 | 18/20 | 0.81 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | HTR1F | P30939 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 1/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | HTR5A | P47898 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370249 | 0.90 | HTR1D (1.00) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL5367977 | 0.88 | HTR1D (0.76) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL6394471 | 0.82 | HTR1D (1.00) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL6391699 | 0.81 | HTR1D (0.73) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL5341152 | 0.81 | HTR1D (0.79) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL5350600 | 0.79 | HTR1D (0.83) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL5346893 | 0.78 | HTR1D (1.00) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL6392574 | 0.76 | HTR1D (1.00) | HTR1DHTR1BHTR1A | |
| SCHEMBL6400107 | 0.76 | HTR1D (1.00) | HTR1DHTR1BHTR1AADRB2DRD2 | |
| SCHEMBL6399387 | 0.75 | HTR1D (0.80) | HTR1DHTR1BHTR1AADRB2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476444-A1 | HETEROCYCLIC COMPOUNDS POSSESSING AFFINITY AT 5HT1-TYPE RECEPTORS AND USE THEREOF IN THERAPY | GLAXO GROUP LIMITED (GB) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068772-A1 | HETEROCYCLIC COMPOUNDS POSSESSING AFFINITY AT 5HT1-TYPE RECEPTORS AND USE THEREOF IN THERAPY | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |