Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 14/20 | 0.55 |
| ▸ | AURKA | O14965 | 10/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664479 | 0.90 | RPS6KB1 (0.51) | RPS6KB1AURKAAURKB | |
| SCHEMBL665089 | 0.84 | RPS6KB1 (0.53) | RPS6KB1AURKAAURKBAKT1 | |
| SCHEMBL665173 | 0.79 | RPS6KB1 (0.63) | RPS6KB1AURKAAURKB | |
| SCHEMBL665241 | 0.79 | AURKA (0.52) | RPS6KB1AURKAAURKBAKT1 | |
| SCHEMBL666581 | 0.73 | RPS6KB1 (0.59) | RPS6KB1AURKAAURKBSIRT2 | |
| SCHEMBL663753 | 0.73 | RPS6KB1 (0.58) | RPS6KB1AURKAAURKBAKT1 | |
| SCHEMBL667105 | 0.71 | RPS6KB1 (0.82) | RPS6KB1AURKAAURKB | |
| SCHEMBL663204 | 0.71 | RPS6KB1 (1.00) | RPS6KB1AURKA | |
| SCHEMBL666537 | 0.67 | RPS6KB1 (0.74) | RPS6KB1AURKA | |
| SCHEMBL667093 | 0.67 | RPS6KB1 (0.60) | RPS6KB1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637532-B2 | Amino azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2014-01-28 | — | — | US | disclosed |
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | RPS6KB1 500/4885AURKA 600/4885AURKB 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.