Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 12/20 | 0.72 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6652261 | 1.00 | DHODH (0.72) | DHODHGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL8714895 | 0.89 | DHODH (0.69) | DHODHGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL8714900 | 0.89 | DHODH (0.69) | DHODHGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL8810580 | 0.87 | DHODH (0.67) | DHODHGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL9092492 | 0.87 | DHODH (0.67) | DHODHGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL9182276 | 0.86 | DHODH (0.56) | DHODHGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL9182280 | 0.86 | DHODH (0.56) | DHODHGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL23752183 | 0.84 | DHODH (1.00) | DHODHGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL5914887 | 0.83 | DHODH (0.70) | DHODHGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL5914889 | 0.83 | DHODH (0.70) | DHODHGAAMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071658-B1 | BTK INHIBITORS AND METHODS FOR THEIR IDENTIFICATION AND USE | PARKER HUGHES INST (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6365626-B1 | LEFLUNOMIDE METABOLITE ANALOGS FOR TREATING IMPROPER PLATELET AGGREGATION; LEUKEMIA; LYMPHOMAS | PARKER HUGHES INSTITUTE | 2002-04-02 | — | — | US | disclosed |