Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 14/20 | 1.00 |
| ▸ | PARP1 | P09874 | 5/20 | 0.56 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.48 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843104 | 0.82 | TYMS (1.00) | TYMS | |
| SCHEMBL6686465 | 0.82 | TYMS (1.00) | TYMSPARP1TNKS2BMPR1BRAF1 | |
| SCHEMBL6653100 | 0.78 | TYMS (1.00) | TYMSPARP1TNKS2BMPR1BRAF1 | |
| SCHEMBL6650293 | 0.75 | TYMS (1.00) | TYMSPARP1 | |
| SCHEMBL6651988 | 0.73 | TYMS (0.68) | TYMSPARP1TNKS2 | |
| SCHEMBL9259148 | 0.73 | PARP1 (1.00) | TYMSPARP1TNKS2BMPR1BRAF1 | |
| SCHEMBL30838794 | 0.73 | PARP1 (1.00) | TYMSPARP1TNKS2BMPR1BRAF1 | |
| SCHEMBL6450968 | 0.71 | TYMS (0.73) | TYMSPARP1 | |
| SCHEMBL6651315 | 0.71 | TYMS (1.00) | TYMS | |
| SCHEMBL2659299 | 0.70 | PARP1 (1.00) | TYMSPARP1TNKS2BMPR1BRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762188-B1 | INHIBITING THYMIDYLATE SYNTHASE; COLON, BREAST OR LUNG CARCINOMA | SMITHKLINE BEECHAM CORPORATION | 2004-07-13 | — | — | US | disclosed |
| EP-1199307-B1 | Pharmaceutically active benzoquinazoline compounds | WELLCOME FOUND (GB) | 2004-02-25 | — | — | EP | disclosed |
| EP-1199307-A1 | Pharmaceutically active benzoquinazoline compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 2002-04-24 | — | — | EP | disclosed |
| US-6306865-B1 | SYNTHASE INHIBITORS AND ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-10-23 | — | — | US | disclosed |
| US-6090941-A | Pharmaceutically active benzoquinazoline compounds | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |
| US-5661155-A | THYMIDYLATE SYNTHASE INHIBITOR; ADMINISTERING TO THE MAMMAL SUFFERING FROM LEUKEMIA OR TUMOR 2-(5-(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLINE-9-YL) METHYL)AMINO)-1-OXO-2-ISOINDOLINYL)GLUTARIC ACID OR SALTS | GLAXO WELLCOME INC. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5405851-A | Administering benzoquinazoline thymidylate synthase inhibitors | BURROUGHS WELLCOME CO. (US) | 1995-04-11 | — | — | US | disclosed |