Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.64 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | STK17B | O94768 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 7/20 | 0.41 |
| ▸ | SRC | P12931 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6654026 | 0.92 | MAPK14 (0.60) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092557 | 0.83 | MAPK14 (0.68) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4087240 | 0.83 | MAPK14 (0.73) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4082244 | 0.81 | MAPK14 (0.69) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4085718 | 0.81 | MAPK14 (0.80) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092362 | 0.80 | MAPK14 (0.72) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4081824 | 0.80 | MAPK14 (0.84) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4082144 | 0.80 | MAPK14 (0.65) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4088020 | 0.79 | MAPK14 (0.75) | MAPK14ABL1RAF1LYNMAPK9 | |
| Thiomorpholine SCHEMBL6621356 | 0.79 | MAPK14 (0.58) | MAPK14ABL1RAF1LYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427412-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-06-16 | — | — | EP | claimed |
| WO-2003022273-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | claimed |
| EP-1427412-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003022273-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |