Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.48 |
| ▸ | PDE4A | P27815 | 5/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6658700 | 0.91 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6657264 | 0.90 | TSHR (0.51) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6656492 | 0.88 | PDE4B (0.61) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6683275 | 0.88 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6658998 | 0.87 | PDE4B (0.63) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6686405 | 0.87 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6841795 | 0.87 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL146176 | 0.86 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6656003 | 0.86 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6837280 | 0.86 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435958-A1 | USE OF PHOSPHORODIESTERASE IV INHIBITORS | MERCK PATENT GmbH (DE) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032993-A1 | USE OF PHOSPHORODIESTERASE IV INHIBITORS | MERCK PATENT GMBH (DE) | 2003-04-24 | — | — | WO | disclosed |
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |