Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CD44 | P16070 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16468973 | 0.70 | PRCP (0.41) | KDM4EMAPT | |
| SCHEMBL1119383 | 0.69 | CD44 (0.46) | KDM4EMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL30425286 | 0.69 | CD44 (0.46) | KDM4EMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL4495963 | 0.67 | NPC1 (0.42) | KDM4EMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL1082367 | 0.67 | SRC (0.49) | KDM4EMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL29661329 | 0.67 | SRC (0.49) | KDM4EMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL10816476 | 0.65 | KDM4E (0.41) | KDM4EMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL3593739 | 0.65 | NPC1 (0.50) | KDM4EMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL9394752 | 0.63 | CD44 (0.36) | KDM4EMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL3600649 | 0.63 | CD44 (0.36) | KDM4EMAPTALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971908-B1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-06-30 | — | — | EP | disclosed |
| US-6436927-B1 | 8-UREIDO AND 8-THIOUREIDO 2,1-BENZOTHIAZINE 2,2-DIOXIDES | SMITHKLINE BEECHAM CORPORATION | 2002-08-20 | — | — | US | disclosed |
| EP-0971908-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM (US) | 2000-05-17 | — | — | EP | disclosed |
| EP-0971908-A1 | IL-8 RECEPTOR ANTAGONISTS | Smithkline Beecham (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998034929-A9 | IL-8 RECEPTOR ANTAGONISTS | — | 1999-01-07 | — | — | WO | disclosed |
| WO-1998034929-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-08-13 | — | — | WO | disclosed |