Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.39 |
| ▸ | PDE4A | P27815 | 10/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657679 | 0.97 | PDE4D (0.39) | PDE4DPDE4APDE4BPDE4CCPT2 | |
| SCHEMBL6656784 | 0.93 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL6655625 | 0.91 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL6660162 | 0.90 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL6660555 | 0.90 | PDE4D (0.39) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL6658460 | 0.89 | PDE4D (0.39) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL6654873 | 0.89 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL6661400 | 0.89 | PDE4D (0.38) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL6662424 | 0.89 | PDE4D (0.38) | PDE4DPDE4APDE4BPDE4CENPP1 | |
| SCHEMBL6683831 | 0.89 | PDE4D (0.38) | PDE4DPDE4APDE4BPDE4CENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435958-A1 | USE OF PHOSPHORODIESTERASE IV INHIBITORS | MERCK PATENT GmbH (DE) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032993-A1 | USE OF PHOSPHORODIESTERASE IV INHIBITORS | MERCK PATENT GMBH (DE) | 2003-04-24 | — | — | WO | disclosed |
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |