SCHEMBL6656909

SCHEMBL6656909

CC(C)(C)Oc1ccccc1C(=O)c1ccc(Nc2ccccc2N)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK13 O15264 10/20 0.65
MAPK12 P53778 10/20 0.65
MAPK11 Q15759 10/20 0.65
MAPK14 Q16539 10/20 0.65
SIRT2 Q8IXJ6 1/20 0.45
MAPT P10636 6/20 0.44
GAA P10253 5/20 0.44
TDP1 Q9NUW8 2/20 0.44
KDM4E B2RXH2 4/20 0.44
ALDH1A1 P00352 3/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
THRB P10828 2/20 0.44
HTT P42858 1/20 0.44
RECQL P46063 1/20 0.44
MMP14 P50281 1/20 0.44
RAB9A P51151 1/20 0.44
HPGD P15428 2/20 0.43
HSD17B10 Q99714 2/20 0.43
TP53 P04637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6651217 0.86 MAPK13 (0.70) MAPK13MAPK12MAPK11MAPK14SIRT2
SCHEMBL6653632 0.81 MAPT (0.51) MAPK13MAPK12MAPK11MAPK14MAPT
SCHEMBL6652431 0.80 ELANE (0.51) MAPTGAAALDH1A1KMT2AHTT
SCHEMBL6653345 0.80 MAPK13 (0.64) MAPK13MAPK12MAPK11MAPK14SIRT2
SCHEMBL6655143 0.79 MAPK14 (0.71) MAPK13MAPK12MAPK11MAPK14MAPT
SCHEMBL6657232 0.79 MAPK14 (1.00) MAPK13MAPK12MAPK11MAPK14SIRT2
SCHEMBL6651327 0.78 MAPK13 (0.58) MAPK13MAPK12MAPK11MAPK14SIRT2
SCHEMBL6655017 0.78 MAPK13 (0.72) MAPK13MAPK12MAPK11MAPK14SIRT2
SCHEMBL6674463 0.77 MAPK13 (0.71) MAPK13MAPK12MAPK11MAPK14SIRT2
SCHEMBL28741706 0.77 ELANE (0.66) MAPTGAATDP1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0966424-B1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF LEO PHARMA AS (DK) 2004-06-23 EP disclosed
US-6313174-B1 FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) 2001-11-06 US disclosed
EP-0966424-A1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1999-12-29 EP disclosed
WO-1998032730-A1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1998-07-30 WO disclosed