Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629864 | 0.84 | HTR2A (0.43) | HRH3HTR2AOPRD1TAAR1CHRNB2 | |
| SCHEMBL7768079 | 0.78 | HRH3 (0.84) | HRH3HDAC8HDAC6CNR2PYCR1 | |
| SCHEMBL12015809 | 0.78 | HRH3 (0.61) | HRH3OPRD1HDAC8HDAC6CNR2 | |
| SCHEMBL4371629 | 0.77 | HRH3 (0.67) | HRH3HDAC8HDAC6CNR2KDM4E | |
| SCHEMBL15270855 | 0.76 | HRH3 (0.59) | HRH3OPRD1HDAC8HDAC6CNR2 | |
| SCHEMBL5234881 | 0.76 | HRH3 (0.53) | HRH3OPRD1HDAC8HDAC6CNR2 | |
| SCHEMBL10178536 | 0.74 | HRH3 (0.57) | HRH3OPRD1HDAC8HDAC6PYCR1 | |
| SCHEMBL6224751 | 0.74 | HRH3 (0.61) | HRH3HTR2ATAAR1HDAC8HDAC6 | |
| SCHEMBL1813157 | 0.73 | HRH3 (0.67) | HRH3HDAC8HDAC6CNR2PYCR1 | |
| SCHEMBL12680476 | 0.72 | HRH3 (1.00) | HRH3TAAR1HDAC8HDAC6CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373233-A1 | DERIVATIVES OF N-(ARYLSULFONYL)BETA-AMINOACIDS COMPRISING A SUBSTITUTED AMINOMETHYL GROUP, THE PREPARATION METHOD THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002076964-A1 | DERIVATIVES OF N-(ARYLSULFONYL)BETA-AMINOACIDS COMPRISING A SUBSTITUTED AMINOMETHYL GROUP, THE PREPARATION METHOD THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-10-03 | — | — | WO | disclosed |