Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | GLA | P06280 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | CASP1 | P29466 | 3/20 | 0.33 |
| ▸ | CASP7 | P55210 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27506717 | 0.78 | HDAC1 (0.31) | — | |
| SCHEMBL29065453 | 0.71 | NPSR1 (0.38) | NPSR1MAPK1KDM4EALDH1A1GLA | |
| SCHEMBL28296127 | 0.70 | NPSR1 (0.34) | NPSR1CHEK1METGSK3BLIMK1 | |
| SCHEMBL6021710 | 0.68 | KDM4E (0.33) | NPSR1MAPK1KDM4EALDH1A1GLA | |
| SCHEMBL30415854 | 0.67 | NPSR1 (0.34) | NPSR1MAPK1KDM4EALDH1A1ATM | |
| SCHEMBL6198946 | 0.64 | — | — | |
| SCHEMBL31435414 | 0.63 | NPSR1 (0.34) | NPSR1MAPK1KDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL22634307 | 0.62 | KDM4E (0.35) | NPSR1MAPK1KDM4EALDH1A1GLA | |
| SCHEMBL5552219 | 0.60 | KDM4E (0.33) | NPSR1MAPK1KDM4EALDH1A1GLA | |
| SCHEMBL12471891 | 0.60 | NPSR1 (0.35) | NPSR1MAPK1KDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440057-A1 | ALLENIC ARYL SULFONAMIDE HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | Wyeth Holdings Corporation (US) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003037852-A1 | ALLENIC ARYL SULFONAMIDE HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | WYETH HOLDINGS CORPORATION (US) | 2003-05-08 | — | — | WO | disclosed |