Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29013944 | 0.76 | GRIN1 (0.36) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL28391485 | 0.73 | GRIN2D (0.32) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL9681620 | 0.72 | — | — | |
| SCHEMBL28113129 | 0.69 | GRIN1 (0.40) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL11023831 | 0.67 | CYP2C19 (0.35) | TSHRALDH1A1 | |
| SCHEMBL25220432 | 0.67 | — | — | |
| SCHEMBL1577155 | 0.67 | ATM (0.45) | TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL25742572 | 0.67 | — | — | |
| SCHEMBL7053478 | 0.67 | CYP2C19 (0.43) | TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL8677429 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442021-A1 | SUBSTITUTED 1H-QUINOLIN-2-ONE COMPOUNDS | Grünenthal GmbH (DE) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037870-A1 | SUBSTITUTED 1H-QUINOLIN-2-ONE COMPOUNDS | Grünenthal GmbH (DE) | 2003-05-08 | — | — | WO | disclosed |