Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 12/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.70 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.70 |
| ▸ | HTR7 | P34969 | 1/20 | 0.69 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084006 | 1.00 | ADORA1 (0.72) | ADORA1ADORA3ADORA2AADORA2BHIF1A | |
| SCHEMBL10866451 | 0.86 | ADORA1 (0.76) | ADORA1ADORA3ADORA2AADORA2BHIF1A | |
| SCHEMBL14903066 | 0.84 | ADORA1 (0.84) | ADORA1ADORA3ADORA2AADORA2BHIF1A | |
| SCHEMBL6661752 | 0.84 | ADORA1 (1.00) | ADORA1ADORA3ADORA2AADORA2BHIF1A | |
| SCHEMBL6663426 | 0.84 | ADORA1 (1.00) | ADORA1ADORA3ADORA2AADORA2BHIF1A | |
| SCHEMBL6663421 | 0.84 | ADORA1 (1.00) | ADORA1ADORA3ADORA2AADORA2BHIF1A | |
| SCHEMBL6661744 | 0.84 | ADORA1 (1.00) | ADORA1ADORA3ADORA2AADORA2BHIF1A | |
| SCHEMBL6659306 | 0.83 | ADORA1 (0.71) | ADORA1ADORA3ADORA2AADORA2BHIF1A | |
| SCHEMBL6659314 | 0.83 | ADORA1 (0.71) | ADORA1ADORA3ADORA2AADORA2BHIF1A | |
| SCHEMBL7067829 | 0.83 | ADORA1 (0.78) | ADORA1ADORA3ADORA2AADORA2BHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1457495-A1 | Adenosine A1 receptor agonists | GLAXO GROUP LIMITED (GB) | 2004-09-15 | — | — | EP | claimed |
| EP-1030857-B1 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| US-6455510-B1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2002-09-24 | — | — | US | claimed |
| EP-1030857-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-30 | — | — | EP | claimed |
| WO-1999024449-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | claimed |
| EP-1457495-A1 | Adenosine A1 receptor agonists | GLAXO GROUP LIMITED (GB) | 2004-09-15 | — | — | EP | disclosed |
| EP-1030857-B1 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| US-6455510-B1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2002-09-24 | — | — | US | disclosed |
| EP-1030857-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024449-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |