Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 9/20 | 0.50 |
| ▸ | CA1 | P00915 | 6/20 | 0.47 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | CA4 | P22748 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662893 | 0.88 | CCNA2 (0.56) | CA9CA1CA2CA4CCNA2 | |
| SCHEMBL6634331 | 0.87 | CCNA2 (0.49) | CA9CA1CA2CA4KDM4E | |
| SCHEMBL6792450 | 0.79 | CCNA2 (0.50) | CA9KDM4EALDH1A1HPGDTP53 | |
| SCHEMBL6660718 | 0.78 | CA9 (0.55) | CA9CA1CA2CA4KDM4E | |
| SCHEMBL5254020 | 0.76 | CCNA2 (0.50) | CA9CA1CA2CA4KDM4E | |
| SCHEMBL5371941 | 0.76 | CA9 (0.50) | CA9CA1CA2CA4KDM4E | |
| SCHEMBL5228990 | 0.76 | CCNA2 (0.79) | CCNA2CDK2CCNA1IKBKB | |
| SCHEMBL5254155 | 0.76 | CA9 (0.53) | CA9CA1CA2CA4KDM4E | |
| SCHEMBL6792114 | 0.76 | CCNA2 (0.50) | CA9CA1CA2CA4KDM4E | |
| SCHEMBL6792645 | 0.76 | CCNA2 (0.54) | KDM4EALDH1A1HPGDTP53CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476431-A1 | TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-11-17 | — | — | EP | claimed |
| WO-2003070706-A1 | TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-08-28 | — | — | WO | claimed |
| EP-1476431-A1 | TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003070706-A1 | TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-08-28 | — | — | WO | disclosed |