Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 18/20 | 0.86 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.86 |
| ▸ | RPS6KB1 | P23443 | 17/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL666059 | 0.92 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL27830110 | 0.86 | AURKA (0.74) | AURKAAURKBRPS6KB1 | |
| SCHEMBL666700 | 0.82 | RPS6KB1 (0.86) | AURKAAURKBRPS6KB1 | |
| SCHEMBL664171 | 0.81 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL665367 | 0.78 | AURKA (0.85) | AURKAAURKBRPS6KB1 | |
| SCHEMBL668843 | 0.78 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL665681 | 0.78 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL669051 | 0.77 | RPS6KB1 (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL669052 | 0.77 | RPS6KB1 (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL666018 | 0.77 | AURKA (1.00) | AURKAAURKBRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396307-B1 | NOVEL AMINO AZAHETEROCYCLIC CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2014-10-15 | — | — | EP | disclosed |
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | AURKA 600/4885AURKB 550/4885RPS6KB1 500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.