Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.78 |
| ▸ | AURKB | Q96GD4 | 17/20 | 0.78 |
| ▸ | RPS6KB1 | P23443 | 14/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16459429 | 0.91 | AURKA (0.65) | AURKAAURKBRPS6KB1 | |
| SCHEMBL666509 | 0.88 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL667436 | 0.79 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL665637 | 0.79 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL665409 | 0.78 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL666290 | 0.78 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL665843 | 0.77 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL10255855 | 0.77 | AURKA (1.00) | AURKAAURKBRPS6KB1 | |
| SCHEMBL667240 | 0.76 | AURKA (0.88) | AURKAAURKBRPS6KB1 | |
| SCHEMBL10256025 | 0.76 | AURKA (1.00) | AURKAAURKBRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637532-B2 | Amino azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2014-01-28 | — | — | US | disclosed |
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | AURKA 600/4885AURKB 550/4885RPS6KB1 500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.