Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.69 |
| ▸ | BRAF | P15056 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 4/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2885798 | 0.85 | CDK2 (0.73) | CDK2BRAFSCN5ASCN9AKCNH2 | |
| SCHEMBL6302354 | 0.82 | CDK2 (0.69) | CDK2BRAFGAAMEN1KMT2A | |
| SCHEMBL1678613 | 0.81 | CDK2 (1.00) | CDK2BRAFMEN1KMT2ASCN5A | |
| SCHEMBL2932811 | 0.80 | CDK2 (0.66) | CDK2BRAFGAAKMT2ASMN1; SMN2 | |
| SCHEMBL6662179 | 0.80 | CDK2 (0.66) | CDK2BRAFMEN1KMT2APOLB | |
| SCHEMBL1122444 | 0.79 | CDK2 (0.65) | CDK2BRAFGAAMEN1KMT2A | |
| SCHEMBL6656588 | 0.79 | BRAF (0.62) | CDK2BRAFSMN1; SMN2POLBMAPT | |
| SCHEMBL16739547 | 0.78 | CDK2 (0.63) | CDK2BRAFSCN5ASCN9AKCNH2 | |
| SCHEMBL6659290 | 0.76 | CDK2 (1.00) | CDK2MEN1KMT2A | |
| SCHEMBL6662729 | 0.74 | CDK2 (0.72) | CDK2BRAFMEN1KMT2AGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004004730-A2 | 2-AMINOPYRAZINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | claimed |
| WO-2004004730-A2 | 2-AMINOPYRAZINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |