Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.50 |
| ▸ | LCK | P06239 | 16/20 | 0.50 |
| ▸ | TEK | Q02763 | 16/20 | 0.50 |
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.42 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801943 | 0.88 | SRC (0.64) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL5801946 | 0.88 | SRC (0.64) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL7152942 | 0.86 | SRC (0.60) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL5819900 | 0.86 | SRC (0.51) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL5819873 | 0.81 | ABL1 (0.61) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL5812726 | 0.79 | SRC (0.61) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL6433865 | 0.78 | SRC (0.68) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL5786214 | 0.78 | SRC (0.68) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL6664730 | 0.77 | SRC (0.44) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL7142942 | 0.77 | SRC (0.70) | SRCLCKTEKKDRLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212327-B8 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2004-02-25 | — | — | EP | disclosed |
| EP-1212327-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019829-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |