Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.93 |
| ▸ | MAPT | P10636 | 7/20 | 0.93 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.93 |
| ▸ | MEN1 | O00255 | 3/20 | 0.93 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.93 |
| ▸ | HTT | P42858 | 2/20 | 0.93 |
| ▸ | HPGD | P15428 | 1/20 | 0.93 |
| ▸ | HBB | P68871 | 1/20 | 0.93 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.93 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.93 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29357684 | 0.97 | MAPT (1.00) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL37700 | 0.97 | MAPT (1.00) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| Water SCHEMBL28844053 | 0.95 | MAPT (0.97) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| Iodide SCHEMBL33722025 | 0.95 | MAPT (0.97) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| Acetic Acid SCHEMBL3457064 | 0.94 | KDM4E (0.82) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| 1,2-Dichlorobenzene SCHEMBL28513476 | 0.89 | MAPT (0.85) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| Succinamide SCHEMBL9208547 | 0.88 | KDM4E (0.78) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL350783 | 0.88 | KDM4E (0.82) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL29411076 | 0.88 | KDM4E (0.82) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL1683342 | 0.86 | KDM4E (0.81) | KDM4EMAPTKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9326993-B2 | Treatment of pulmonary and pleural fibrosis using HSP27 inhibitors | ONCOGENEX TECHNOLOGIES INC. (CA) | 2016-05-03 | — | — | US | disclosed |
| US-20150126584-A1 | Treatment of Pulmonary and Pleural Fibrosis Using HSP27 Inhibitors | ONCOGENEX TECHNOLOGIES INC. (CA) | 2015-05-07 | — | — | US | disclosed |
| US-8987223-B2 | Treatment of pulmonary and pleural fibrosis using HSP27 inhibitors | ONCOGENEX TECHNOLOGIES INC. (CA) | 2015-03-24 | — | — | US | disclosed |
| US-20120294846-A1 | Treatment of Pulmonary and Pleural Fibrosis Using HSP27 Inhibitors | ONCOGENEX TECHNOLOGIES INC. (CA) | 2012-11-22 | — | — | US | disclosed |
| EP-0912741-B1 | T-CELL SELECTIVE INTERLEUKIN-4 AGONISTS | BAYER AG (US) | 2004-07-28 | — | — | EP | disclosed |
| US-6433157-B1 | POLYNUCLEOTIDE MOLECULE ENCODING HUMAN INTERLEUKIN-4 MUTEIN HAVING MUTATED SURFACE EXPOSED RESIDUES OF D HELIX, WHICH CAUSES T-CELL PROLIFERATION AND REDUCED INTERLEUKIN-6 SECRETION FROM HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS | BAYER CORPORATION | 2002-08-13 | — | — | US | disclosed |
| US-5986059-A | POLYPEPTIDES AND INTERLEUKINS | BAYER CORPORATION (US) | 1999-11-16 | — | — | US | disclosed |
| EP-0912741-A2 | T-CELL SELECTIVE INTERLEUKIN-4 AGONISTS | Bayer Corporation (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997047744-A2 | T-CELL SELECTIVE INTERLEUKIN-4 AGONISTS | BAYER CORPORATION (US) | 1997-12-18 | — | — | WO | disclosed |