Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 11/20 | 0.61 |
| ▸ | RPS6KB1 | P23443 | 11/20 | 0.61 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3705480 | 0.88 | RPS6KB1 (0.68) | PDPK1RPS6KB1AURKAAURKBJAK1 | |
| SCHEMBL28794180 | 0.88 | RPS6KB1 (0.68) | PDPK1RPS6KB1AURKAAURKBJAK1 | |
| SCHEMBL664715 | 0.87 | PIK3CD (0.47) | PDPK1RPS6KB1BTKAURKAAURKB | |
| SCHEMBL31721617 | 0.84 | RPS6KB1 (0.52) | PDPK1RPS6KB1BTKAURKAAURKB | |
| SCHEMBL30609400 | 0.84 | PIK3CD (0.47) | PDPK1RPS6KB1BTKAURKAAURKB | |
| SCHEMBL31721666 | 0.81 | PDPK1 (0.46) | PDPK1RPS6KB1BTKAURKAAURKB | |
| SCHEMBL31721721 | 0.81 | PDPK1 (0.46) | PDPK1RPS6KB1BTKAURKAAURKB | |
| SCHEMBL31507168 | 0.80 | PIK3CD (0.47) | PDPK1RPS6KB1USP30BTKPIK3CD | |
| SCHEMBL30609319 | 0.80 | PIK3CD (0.47) | PDPK1RPS6KB1USP30BTKPIK3CD | |
| SCHEMBL31507150 | 0.80 | PARP1 (0.49) | USP30BTKPIK3CDPARP1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | PDPK1 2787/4885RPS6KB1 500/4885USP30 1370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.