Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 1.00 |
| ▸ | EGFR | P00533 | 8/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | PIM1 | P11309 | 1/20 | 0.69 |
| ▸ | PRKACA | P17612 | 1/20 | 0.69 |
| ▸ | LTK | P29376 | 1/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.69 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.69 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.69 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.69 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.69 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.69 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.69 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8810621 | 0.84 | ABCG2 (0.72) | ABCG2EGFRERBB2AURKBCLK4 | |
| Hydrochloric Acid SCHEMBL9017046 | 0.83 | ABCG2 (0.97) | ABCG2EGFRERBB2AURKBCLK4 | |
| SCHEMBL6684273 | 0.82 | ABCG2 (0.67) | ABCG2EGFRERBB2AURKBCLK4 | |
| SCHEMBL8920 | 0.82 | EGFR (1.00) | ABCG2EGFRERBB2AURKBCLK4 | |
| SCHEMBL29941271 | 0.82 | EGFR (1.00) | ABCG2EGFRERBB2AURKBCLK4 | |
| SCHEMBL6684283 | 0.81 | ABCG2 (0.66) | ABCG2EGFRERBB2AURKBCLK4 | |
| SCHEMBL6686019 | 0.81 | ABCG2 (0.66) | ABCG2EGFRERBB2AURKBCLK4 | |
| Hydrochloric Acid SCHEMBL8808235 | 0.81 | EGFR (0.90) | ABCG2EGFRERBB2AURKBCLK4 | |
| Hydrochloric Acid SCHEMBL20856873 | 0.80 | EGFR (0.96) | ABCG2EGFRERBB2AURKBCLK4 | |
| Hydrochloric Acid SCHEMBL29394578 | 0.80 | EGFR (0.96) | ABCG2EGFRERBB2AURKBCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |