SCHEMBL6663014

SCHEMBL6663014

O=C(C1CCCCN1Cc1ccccc1)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.54
NPSR1 Q6W5P4 2/20 0.54
LMNA P02545 1/20 0.54
MCHR1 Q99705 1/20 0.54
CNR1 P21554 1/20 0.52
CNR2 P34972 1/20 0.52
ATM Q13315 2/20 0.52
CACNA2D1 P54289 1/20 0.52
CACNA1B Q00975 1/20 0.52
CACNB1 Q02641 1/20 0.52
CACNA1C Q13936 1/20 0.52
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
DPP8 Q6V1X1 1/20 0.51
DPP7 Q9UHL4 1/20 0.51
CACNA1G O43497 1/20 0.50
ALDH1A1 P00352 3/20 0.49
KDM4E B2RXH2 1/20 0.48
HTT P42858 1/20 0.48
HRH3 Q9Y5N1 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6908549 1.00 MAPT (0.54) MAPTNPSR1LMNAMCHR1CNR1
SCHEMBL6664757 0.96 KMT2A (0.57) MAPTNPSR1LMNAMCHR1CNR1
SCHEMBL6664762 0.96 KMT2A (0.57) MAPTNPSR1LMNAMCHR1CNR1
SCHEMBL6659166 0.95 DPP8 (0.49) MAPTNPSR1LMNAMCHR1CNR1
SCHEMBL6660540 0.92 NPSR1 (0.62) MAPTNPSR1LMNAMCHR1CNR1
SCHEMBL6909802 0.92 NPSR1 (0.62) MAPTNPSR1LMNAMCHR1CNR1
Hydrochloric Acid SCHEMBL6684989 0.87 NPSR1 (0.56) MAPTNPSR1LMNACNR1CNR2
Hydrochloric Acid SCHEMBL6684980 0.87 NPSR1 (0.56) MAPTNPSR1LMNACNR1CNR2
SCHEMBL6902204 0.85 DPP8 (0.50) MAPTNPSR1LMNACNR1CNR2
SCHEMBL6662353 0.85 DPP8 (0.50) MAPTNPSR1LMNACNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1441728-A2 MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY Vertex Pharmaceuticals Incorporated (US) 2004-08-04 EP disclosed
WO-2003037338-A2 MODULATORS OF THE CHOLESTEROL BIOSYNTHETIC PATHWAY VERTEX PHARMACEUTICALS INCORPORATED (US) 2003-05-08 WO disclosed
EP-1257544-A2 PIPERAZINE AND PIPERIDINE DERIVATIVES FOR TREATMENT OR PREVENTION OF NEURONAL DAMAGE Vertex Pharmaceuticals Incorporated (US) 2002-11-20 EP disclosed
WO-2001058891-A2 PIPERAZINE AND PIPERIDINE DERIVATIVES FOR TREATMENT OR PREVENTION OF NEURONAL DAMAGE VERTEX PHARMACEUTICALS INCORPORATED (US) 2001-08-16 WO disclosed