Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.30 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884423 | 0.74 | — | — | |
| SCHEMBL27474993 | 0.72 | — | — | |
| SCHEMBL5606195 | 0.72 | — | — | |
| SCHEMBL193546 | 0.72 | — | — | |
| SCHEMBL4597159 | 0.72 | TSHR (0.32) | LMNATSHRNFKB1CYP1A2MAOA | |
| SCHEMBL1526166 | 0.70 | — | — | |
| SCHEMBL7615586 | 0.69 | — | — | |
| SCHEMBL867273 | 0.68 | — | — | |
| SCHEMBL11662658 | 0.68 | SLC7A5 (0.39) | LMNA | |
| SCHEMBL7782861 | 0.68 | MEN1 (0.38) | GABRR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1160571-B1 | Interference-eliminating membranes, test strips, kits and methods for use in uric acid assay | DEV CENTER BIOTECHNOLOGY (TW) | 2004-08-04 | — | — | EP | claimed |
| US-6699720-B1 | COMPRISING ONE OR MORE REACTION LAYERS INCLUDING TEST REAGENTS AND A CARRIER; AMMONIUM PHOSPHOTUNGSTATE (PH 2-5), CITRATE, COPPER 2+ IONS; | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2004-03-02 | — | — | US | claimed |
| EP-1160571-A1 | Interference-eliminating membranes, test strips, kits and methods for use in uric acid assay | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2001-12-05 | — | — | EP | claimed |
| EP-1160571-B1 | Interference-eliminating membranes, test strips, kits and methods for use in uric acid assay | DEV CENTER BIOTECHNOLOGY (TW) | 2004-08-04 | — | — | EP | disclosed |
| US-6699720-B1 | COMPRISING ONE OR MORE REACTION LAYERS INCLUDING TEST REAGENTS AND A CARRIER; AMMONIUM PHOSPHOTUNGSTATE (PH 2-5), CITRATE, COPPER 2+ IONS; | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2004-03-02 | — | — | US | disclosed |
| EP-1160571-A1 | Interference-eliminating membranes, test strips, kits and methods for use in uric acid assay | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2001-12-05 | — | — | EP | disclosed |