Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | REN | P00797 | 4/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313008 | 0.84 | KLK5 (0.52) | KLK5ATMBACE1RENPSEN1 | |
| SCHEMBL6308523 | 0.84 | KLK5 (0.52) | KLK5ATMBACE1RENPSEN1 | |
| SCHEMBL17297218 | 0.75 | PTPRB (0.55) | ATMCTSSCTSLCTSBCTSK | |
| SCHEMBL10411484 | 0.75 | PTPRB (0.55) | ATMCTSSCTSLCTSBCTSK | |
| SCHEMBL9725769 | 0.75 | KLK5 (0.51) | KLK5ATMBACE1PSEN1PSEN2 | |
| SCHEMBL7277293 | 0.75 | KLK5 (0.51) | KLK5ATMBACE1PSEN1PSEN2 | |
| SCHEMBL6356044 | 0.75 | KLK5 (0.51) | KLK5ATMBACE1PSEN1PSEN2 | |
| SCHEMBL7364763 | 0.75 | KLK5 (0.51) | KLK5ATMBACE1PSEN1PSEN2 | |
| SCHEMBL6669325 | 0.74 | ATM (0.41) | KLK5ATMCTSSCTSLCTSB | |
| SCHEMBL7492257 | 0.73 | PSEN1 (0.57) | KLK5BACE1RENPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450795-A1 | PEPTIDE ISOSTERES CONTAINING A HETEROCYCLE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003047576-A1 | PEPTIDE ISOSTERES CONTAINING A HETEROCYCLE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-06-12 | — | — | WO | disclosed |