Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.73 |
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 8/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | F9 | P00740 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.55 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27529543 | 0.88 | EGFR (0.69) | ABCG2HTTMAPK1KDM4EEGFR | |
| Hydrochloric Acid SCHEMBL1507507 | 0.86 | EGFR (0.67) | ABCG2HTTMAPK1KDM4EEGFR | |
| SCHEMBL8871863 | 0.85 | EGFR (0.82) | HTTMAPK1KDM4EEGFRERBB2 | |
| SCHEMBL1507715 | 0.84 | ABCG2 (0.71) | ABCG2EGFRERBB2MAPTLMNA | |
| Hydrochloric Acid SCHEMBL9017046 | 0.83 | ABCG2 (0.97) | ABCG2HTTEGFRERBB2LMNA | |
| SCHEMBL2101381 | 0.81 | HTT (1.00) | ABCG2HTTMAPK1KDM4EEGFR | |
| SCHEMBL5565226 | 0.81 | HTT (0.72) | ABCG2HTTMAPK1KDM4EEGFR | |
| SCHEMBL4741685 | 0.81 | EGFR (0.80) | HTTMAPK1KDM4EEGFRERBB2 | |
| SCHEMBL5569022 | 0.81 | HTT (0.72) | HTTMAPK1KDM4EEGFRERBB2 | |
| SCHEMBL5564456 | 0.81 | MAPK1 (0.82) | ABCG2HTTMAPK1KDM4EEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |