Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.98 |
| ▸ | ESR2 | Q92731 | 17/20 | 0.98 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.81 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.81 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | TP53 | P04637 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.76 |
| ▸ | PLD2 | O14939 | 1/20 | 0.76 |
| ▸ | KDM1A | O60341 | 1/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.76 |
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | C5 | P01031 | 1/20 | 0.76 |
| ▸ | FYN | P06241 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665661 | 0.99 | ESR1 (1.00) | ESR1ESR2ENPP1ENPP3MEN1 | |
| SCHEMBL6595860 | 0.99 | ESR1 (0.96) | ESR1ESR2ENPP1ENPP3MEN1 | |
| Bromide SCHEMBL1665326 | 0.98 | ESR1 (0.98) | ESR1ESR2ENPP1ENPP3MEN1 | |
| Hydrochloric Acid SCHEMBL2495864 | 0.98 | ESR1 (1.00) | ESR1ESR2ENPP1ENPP3MEN1 | |
| SCHEMBL7632970 | 0.98 | ESR1 (0.98) | ESR1ESR2ENPP1ENPP3MEN1 | |
| Hydrochloric Acid SCHEMBL1665332 | 0.98 | ESR1 (1.00) | ESR1ESR2ENPP1ENPP3MEN1 | |
| SCHEMBL7669007 | 0.95 | ESR1 (0.89) | ESR1ESR2ENPP1ENPP3MEN1 | |
| SCHEMBL7451142 | 0.95 | ESR1 (0.89) | ESR1ESR2ENPP1ENPP3MEN1 | |
| SCHEMBL11550698 | 0.94 | ESR1 (1.00) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL6597408 | 0.94 | ESR1 (0.88) | ESR1ESR2ENPP1ENPP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873051-B1 | MODULATION OF CALCIUM CHANNELS | LILLY CO ELI (US) | 2004-08-04 | — | — | EP | disclosed |
| EP-0831822-B1 | The use of calcium channel antagonists for treating cardiac, renal and gastrointestinal disorders and hypertension | LILLY CO ELI (US) | 2003-10-29 | — | — | EP | disclosed |
| EP-0831822-A4 | CALCIUM CHANNEL ANTAGONISTS | LILLY CO ELI (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0873051-A4 | MODULATION OF CALCIUM CHANNELS | LILLY CO ELI (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0873051-A1 | MODULATION OF CALCIUM CHANNELS | ELI LILLY AND COMPANY (US) | 1998-10-28 | — | — | EP | disclosed |
| EP-0831822-A1 | CALCIUM CHANNEL ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040134-A1 | CALCIUM CHANNEL ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996039833-A1 | MODULATION OF CALCIUM CHANNELS | ELI LILLY AND COMPANY (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5571808-A | SUBSTITUTED 2-ARYL-3-AROYLBENZO(B)THIOPHENES | ELI LILLY AND COMPANY (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0724881-A1 | Method for treating smoking-related bone loss | ELI LILLY AND COMPANY (US) | 1996-08-07 | — | — | EP | disclosed |
| US-5532254-A | CARDIOVASCULAR | ELI LILLY AND COMPANY (US) | 1996-07-02 | — | — | US | disclosed |
| US-4133814-A | ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1979-01-09 | — | — | US | disclosed |