Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 6/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.37 |
| ▸ | RAF1 | P04049 | 5/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69080 | 0.94 | CSNK1A1 (0.37) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL68123 | 0.84 | RAF1 (0.55) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL68206 | 0.80 | CSNK1A1 (0.51) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL68623 | 0.80 | CSNK1A1 (0.44) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL69079 | 0.76 | PDGFRB (0.45) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL66641 | 0.75 | PDGFRB (0.42) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL68513 | 0.74 | KDM4E (0.45) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL67844 | 0.74 | BRAF (0.53) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL66643 | 0.74 | MAPK14 (0.39) | MAPK13MAPK12MAPK11MAPK14MAP3K11 | |
| SCHEMBL68659 | 0.73 | MAPK13 (0.52) | MAPK13MAPK12MAPK11MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | MAPK13 178/4885MAPK12 501/4885MAPK11 362/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | MAPK13 197/4885MAPK12 353/4885MAPK11 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.