SCHEMBL6664409

SCHEMBL6664409

CC(=O)c1ccc(-c2ccccc2)c(C(=O)Nc2ccc3c(c2)CCN3C(=O)Cc2ccccn2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EIF2AK3 Q9NZJ5 1/20 0.48
SMO Q99835 2/20 0.47
RAB9A P51151 2/20 0.44
NPC1 O15118 1/20 0.44
TP53 P04637 1/20 0.44
MAPT P10636 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
SYK P43405 3/20 0.43
AURKB Q96GD4 1/20 0.42
INCENP Q9NQS7 1/20 0.42
AVPR2 P30518 1/20 0.42
OXTR P30559 1/20 0.42
AVPR1A P37288 1/20 0.42
CYP11B1 P15538 1/20 0.41
CYP11B2 P19099 1/20 0.41
HTR2C P28335 2/20 0.41
HTR2B P41595 2/20 0.41
CREBBP Q92793 2/20 0.41
HTR2A P28223 1/20 0.41
NPY2R P49146 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6664793 0.94 EIF2AK3 (0.46) EIF2AK3SMORAB9ANPC1TP53
SCHEMBL6661936 0.94 SMO (0.47) EIF2AK3SMORAB9ANPC1TP53
SCHEMBL6799240 0.92 EIF2AK3 (0.49) EIF2AK3SMORAB9ANPC1TP53
SCHEMBL6664878 0.91 EIF2AK3 (0.48) EIF2AK3SMORAB9ANPC1TP53
SCHEMBL6667760 0.89 EIF2AK3 (0.47) EIF2AK3SMOMAPTSYKAVPR2
SCHEMBL6665157 0.89 SMO (0.49) EIF2AK3SMORAB9ASYKAVPR2
SCHEMBL6664314 0.89 SMO (0.47) EIF2AK3SMOSYKAVPR2AVPR1A
SCHEMBL6663993 0.89 EIF2AK3 (0.50) EIF2AK3SMORAB9ASYKAURKB
SCHEMBL6664835 0.89 EIF2AK3 (0.46) EIF2AK3SMOMAPTSYKCYP11B1
SCHEMBL6668674 0.89 EIF2AK3 (0.46) EIF2AK3SMORAB9ANPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1383760-A1 BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-01-28 EP disclosed
WO-2002090347-A1 AMIDE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-11-14 WO disclosed