Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.37 |
| ▸ | RAF1 | P04049 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | FLT4 | P35916 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | CCR9 | P51686 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4978637 | 0.88 | KDR (0.35) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL4976646 | 0.81 | KDR (0.37) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL4983374 | 0.80 | BRAF (0.44) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL4978649 | 0.80 | BRD4 (0.35) | BRAFRAF1RORCGCGRMT-CO2 | |
| SCHEMBL4978772 | 0.80 | KDR (0.37) | RAF1PDGFRBKITFLT1FLT4 | |
| SCHEMBL4980540 | 0.79 | MAPK14 (0.35) | KITKDRGCGRMT-CO2CYP3A4 | |
| SCHEMBL4978572 | 0.79 | MAPK14 (0.37) | LCKKITKDRSRCGCGR | |
| SCHEMBL14274187 | 0.78 | KDR (0.34) | PDGFRBKITFLT1FLT4KDR | |
| SCHEMBL4978634 | 0.78 | BRAF (0.37) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL4978681 | 0.77 | MAPT (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487824-A1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003074515-A1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-12 | — | — | WO | disclosed |