Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 7/20 | 0.69 |
| ▸ | DPP4 | P27487 | 12/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.57 |
| ▸ | FAP | Q12884 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL666481 | 1.00 | PREP (0.69) | PREPDPP4ADRB2ADRB1DPP8 | |
| SCHEMBL7169242 | 1.00 | PREP (0.69) | PREPDPP4ADRB2ADRB1DPP8 | |
| SCHEMBL664749 | 0.77 | DPP4 (1.00) | PREPDPP4DPP8DPP7FAP | |
| SCHEMBL664750 | 0.77 | DPP4 (1.00) | PREPDPP4DPP8DPP7FAP | |
| Dimethylamine SCHEMBL665713 | 0.76 | DPP4 (0.65) | PREPDPP4DPP8DPP7 | |
| Dimethylamine SCHEMBL666588 | 0.76 | DPP4 (0.65) | PREPDPP4DPP8DPP7 | |
| SCHEMBL666975 | 0.75 | DPP4 (0.77) | PREPDPP4DPP8DPP7FAP | |
| SCHEMBL666976 | 0.75 | DPP4 (0.77) | PREPDPP4DPP8DPP7FAP | |
| SCHEMBL665439 | 0.75 | DPP4 (0.64) | PREPDPP4DPP8DPP7FAP | |
| SCHEMBL666567 | 0.75 | DPP4 (0.69) | PREPDPP4DPP8DPP7FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120045509-A1 | MODIFIED RELEASE COMPOSITIONS FOR DPP-IV INHIBITORS | LOEFFLER BERND MICHAEL (CH) | 2012-02-23 | — | — | US | disclosed |
| EP-1441719-B1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-30 | — | — | EP | disclosed |
| US-7314884-B2 | non-insulin dependent diabetes mellitus, and impaired glucose tolerance; dipeptidyl peptidase IV (DPP-IV) inhibitors eg (2S)-1-{[(1S)-2-(5-cyano-2-methyl-indol-1-yl)-1-methyl-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile | HOFFMANN-LA ROCHE INC. (US) | 2008-01-01 | — | — | US | disclosed |
| US-20070259925-A1 | DPP IV INHIBITORS | BOEHRINGER MARKUS | 2007-11-08 | — | — | US | disclosed |
| US-20070098781-A1 | Modified release compositions for DPP-IV inhibitors | HOFFMANN-LA ROCHE INC. | 2007-05-03 | — | — | US | disclosed |
| US-20050096348-A1 | DPP IV inhibitors | BOEHRINGER MARKUS (CH) | 2005-05-05 | — | — | US | disclosed |
| US-6861440-B2 | DPP IV inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20030130281-A1 | DPP IV inhibitors | HOFFMAN-LA ROCHE INC. | 2003-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070098781-A1 | Modified release compositions for DPP-IV inhibitors | DPP4, DPP3, DPP7 | PREP 118/4885DPP4 1/4885ADRB2 785/4885 |
| US-20070259925-A1 | DPP IV INHIBITORS | DPP4, DPP3, DPP7 | PREP 99/4885DPP4 1/4885ADRB2 1427/4885 |
| US-20120045509-A1 | MODIFIED RELEASE COMPOSITIONS FOR DPP-IV INHIBITORS | DPP4, DPP3, DPP7 | PREP 118/4885DPP4 1/4885ADRB2 785/4885 |
| US-20030130281-A1 | DPP IV inhibitors | DPP4, DPP3, DPP7 | PREP 173/4885DPP4 1/4885ADRB2 979/4885 |
| US-20050096348-A1 | DPP IV inhibitors | DPP4, DPP3, DPP7 | PREP 99/4885DPP4 1/4885ADRB2 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.