Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575470 | 0.87 | EPHX2 (0.57) | EPHX2NR1H4HTR2CCA12CA1 | |
| SCHEMBL6635990 | 0.85 | EPHX2 (0.61) | EPHX2NR1H4HTR2CCA12CA1 | |
| SCHEMBL3966634 | 0.83 | EPHX2 (0.63) | EPHX2NR1H4HTR2CCYP2C9CYP2C19 | |
| SCHEMBL13338010 | 0.83 | MAPT (0.57) | EPHX2NR1H4HTR2CCA12CA1 | |
| SCHEMBL15682671 | 0.83 | EPHX2 (0.56) | EPHX2NR1H4HTR2CCA12CA1 | |
| Hydrochloric Acid SCHEMBL30996820 | 0.82 | EPHX2 (0.51) | EPHX2NR1H4HTR2CCA12CA1 | |
| SCHEMBL27859550 | 0.82 | EPHX2 (0.62) | EPHX2NR1H4HTR2CCYP2C9CYP2C19 | |
| SCHEMBL13647056 | 0.81 | MAPK14 (0.63) | EPHX2HTR2CPPARGPPARAEPHX1 | |
| SCHEMBL23564738 | 0.81 | EPHX2 (0.57) | EPHX2NR1H4HTR2CCYP2C9CYP2C19 | |
| SCHEMBL19212325 | 0.81 | EPHX2 (0.57) | EPHX2NR1H4HTR2CCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1863777-A | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor | ABBOTT LAB (US) | 2006-11-15 | — | — | CN | claimed |
| CN-1863777-A | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor | ABBOTT LAB (US) | 2006-11-15 | — | — | CN | disclosed |
| EP-1490340-A1 | HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN | MERCK SHARP & DOHME LTD. (GB) | 2004-12-29 | — | — | EP | disclosed |
| CN-1478084-A | Compounds useful in treatment of inflammatory diseases | — | 2004-02-25 | — | — | CN | disclosed |
| WO-2003080578-A1 | HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN | MERCK SHARP & DOHME LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |