Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.58 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 6/20 | 0.52 |
| ▸ | TEK | Q02763 | 4/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368680 | 0.81 | FGFR1 (0.55) | FGFR1CSNK2A2CSNK2BCSNK2A1MAPK1 | |
| SCHEMBL14013967 | 0.81 | KDR (0.78) | FGFR1KDRTEKKITLIMK1 | |
| SCHEMBL6642198 | 0.74 | LIMK1 (0.61) | CSNK2A2CSNK2BCSNK2A1MAPK1MEN1 | |
| SCHEMBL2369149 | 0.74 | MEN1 (0.71) | FGFR1MAPK1KITMEN1KMT2A | |
| SCHEMBL10325258 | 0.73 | NOTUM (0.54) | CSNK2A2CSNK2BCSNK2A1MAPK1KDR | |
| SCHEMBL11554443 | 0.73 | CSNK2A2 (0.54) | FGFR1CSNK2A2CSNK2BCSNK2A1MAPK1 | |
| SCHEMBL4480771 | 0.72 | KDR (0.71) | FGFR1CSNK2A2CSNK2BCSNK2A1KDR | |
| SCHEMBL14974794 | 0.72 | PRKCI (0.61) | FGFR1CSNK2A2CSNK2BCSNK2A1MAPK1 | |
| SCHEMBL439136 | 0.71 | NOTUM (0.52) | CSNK2A2CSNK2BCSNK2A1MAPK1ALDH1A1 | |
| SCHEMBL10343546 | 0.71 | LIMK1 (0.44) | CSNK2A2CSNK2BCSNK2A1MAPK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138238-A1 | Substituted aminopyrimidine compounds as neurokinin antagonists | PREDIX PHARMACEUTICALS HOLDINGS, INC. | 2004-07-15 | — | — | US | disclosed |
| WO-2004014850-A2 | SUBSTITUTED AMINOPYRIMIDINES AS NEUROKININ ANTAGONISTS | PREDIX PHARMACEUTICALS HOLDINGS, INC. (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138238-A1 | Substituted aminopyrimidine compounds as neurokinin antagonists | TACR1, GRPR, BDKRB1 | FGFR1 792/4885CSNK2A2 2323/4885CSNK2B 1684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.