Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 5/20 | 0.69 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.65 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30827902 | 0.85 | ALK (0.70) | ALKEGFRABCG2HTTMAPT | |
| SCHEMBL29199908 | 0.85 | ALK (0.70) | ALKEGFRABCG2HTTMAPT | |
| SCHEMBL8871504 | 0.84 | EGFR (0.76) | ALKEGFRABCG2HTTMAPT | |
| SCHEMBL4587672 | 0.83 | ALK (0.79) | ALKEGFRABCG2HTTMAPT | |
| SCHEMBL3244626 | 0.82 | ALK (0.77) | ALKEGFRABCG2HTTMAPT | |
| SCHEMBL1192454 | 0.82 | EGFR (1.00) | ALKEGFRABCG2HTTMAPT | |
| SCHEMBL29116258 | 0.81 | ABCG2 (0.74) | ALKEGFRABCG2HTTMAPT | |
| SCHEMBL5564480 | 0.81 | MAPK1 (0.76) | ALKEGFRHTTMAPTALDH1A1 | |
| SCHEMBL6663823 | 0.80 | ALK (0.74) | ALKEGFRABCG2HTTMAPT | |
| SCHEMBL5473767 | 0.80 | ABCG2 (1.00) | ALKEGFRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |