Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 5/20 | 0.42 |
| ▸ | TACR1 | P25103 | 6/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664259 | 0.92 | TACR2 (0.42) | TACR2TACR1HRH3CCR5OPRK1 | |
| SCHEMBL6665988 | 0.92 | TACR2 (0.43) | TACR2TACR1HRH3CCR5OPRK1 | |
| Hydrochloric Acid SCHEMBL6952736 | 0.92 | TACR2 (0.42) | TACR2TACR1HRH3CCR5OPRK1 | |
| Hydrochloric Acid SCHEMBL6947443 | 0.91 | TACR2 (0.43) | TACR2TACR1HRH3CCR5OPRK1 | |
| SCHEMBL6664427 | 0.89 | TACR1 (0.43) | TACR2TACR1HRH3 | |
| Hydrochloric Acid SCHEMBL6952730 | 0.89 | TACR1 (0.43) | TACR2TACR1HRH3 | |
| SCHEMBL6663281 | 0.83 | TACR2 (0.42) | TACR2TACR1CCR5 | |
| SCHEMBL6663318 | 0.83 | TACR2 (0.40) | TACR2TACR1CCR5OPRK1 | |
| Hydrochloric Acid SCHEMBL6944711 | 0.82 | TACR2 (0.40) | TACR2TACR1CCR5OPRK1 | |
| SCHEMBL6667597 | 0.82 | KMT2A (0.46) | TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165528-B1 | NOVEL MORPHOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | SANOFI SYNTHELABO (FR) | 2004-09-01 | — | — | EP | disclosed |
| US-6506750-B1 | N-(phenylacetyl)morpholine derivatives useful as NK1 receptor antagonists, a process for the preparation thereof, and pharmaceutical compositions containing them as active principle. | SANOFI-SYNTHELABO (FR) | 2003-01-14 | — | — | US | disclosed |
| EP-1165528-A1 | NOVEL MORPHOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000058292-A1 | NOVEL MORPHOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2000-10-05 | — | — | WO | disclosed |