Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | FABP7 | O15540 | 1/20 | 0.50 |
| ▸ | FABP3 | P05413 | 1/20 | 0.50 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17714039 | 0.98 | KMT2A (0.55) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL2760661 | 0.98 | KMT2A (0.55) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| Biphenyl SCHEMBL5704216 | 0.91 | TDP1 (0.50) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL2637327 | 0.91 | HSD17B10 (0.59) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL194962 | 0.91 | HSD17B10 (0.59) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL6230192 | 0.86 | KMT2A (0.53) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| Bicarbonate SCHEMBL27833263 | 0.85 | TDP1 (0.52) | HSD17B10GAAMAPTTDP1KDM4E | |
| SCHEMBL29399270 | 0.84 | HSD17B10 (0.71) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL9154171 | 0.84 | HSD17B10 (0.71) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL1713590 | 0.84 | HSD17B10 (0.71) | KMT2AMEN1SMN1; SMN2LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0727608-B1 | Gas storage apparatus, gaseous fuel automobile using the gas storage apparatus, gas storage method and methane adsorbing-retaining agent | OSAKA GAS CO LTD (JP) | 2004-09-01 | — | — | EP | claimed |