Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662632 | 0.93 | ADRB3 (0.39) | MAPTLMNANPSR1ADRB3ADRB2 | |
| SCHEMBL6664721 | 0.90 | ADRB3 (0.45) | POLBLMNAADRB3ADRB2ADRB1 | |
| SCHEMBL6667993 | 0.89 | CSNK2A2 (0.40) | LMNAADRB3ADRB2ADRB1FGFR1 | |
| SCHEMBL6663327 | 0.89 | ADRB3 (0.41) | POLBTP53MAPTLMNANPSR1 | |
| SCHEMBL6665618 | 0.89 | ADRB3 (0.39) | MAPTLMNANPSR1ADRB3ADRB2 | |
| SCHEMBL6663586 | 0.88 | ADRB3 (0.41) | MAPTLMNAADRB3ADRB2ADRB1 | |
| SCHEMBL6666922 | 0.88 | ADRB3 (0.41) | MAPTLMNANPSR1ADRB3ADRB2 | |
| SCHEMBL6666112 | 0.88 | ADRB3 (0.44) | LMNAADRB3ADRB2ADRB1FGFR1 | |
| SCHEMBL6668266 | 0.87 | ADRB3 (0.38) | MAPTLMNANPSR1ADRB3ADRB2 | |
| SCHEMBL6668018 | 0.85 | ADRB3 (0.39) | LMNAADRB3ADRB2ADRB1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014850-A2 | SUBSTITUTED AMINOPYRIMIDINES AS NEUROKININ ANTAGONISTS | PREDIX PHARMACEUTICALS HOLDINGS, INC. (US) | 2004-02-19 | — | — | WO | disclosed |