Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.58 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.58 |
| ▸ | AKT1 | P31749 | 1/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.51 |
| ▸ | GSK3A | P49840 | 12/20 | 0.47 |
| ▸ | SRC | P12931 | 10/20 | 0.46 |
| ▸ | SYK | P43405 | 10/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667236 | 0.89 | ABL1 (0.60) | ABL1EGFRRAF1LYNBRAF | |
| SCHEMBL6669726 | 0.87 | MAPK14 (0.54) | ABL1EGFRRAF1LYNBRAF | |
| SCHEMBL6664158 | 0.83 | ABL1 (0.63) | ABL1EGFRRAF1LYNBRAF | |
| SCHEMBL6669467 | 0.83 | MAPK14 (0.53) | ABL1EGFRRAF1LYNBRAF | |
| SCHEMBL6883066 | 0.78 | MAPK14 (0.54) | ABL1EGFRRAF1LYNBRAF | |
| SCHEMBL6668838 | 0.76 | MAPK14 (0.53) | ABL1EGFRRAF1LYNBRAF | |
| SCHEMBL6669800 | 0.75 | MAPK14 (0.56) | ABL1EGFRRAF1LYNBRAF | |
| SCHEMBL4092237 | 0.73 | ABL1 (1.00) | ABL1EGFRRAF1LYNBRAF | |
| SCHEMBL13527348 | 0.73 | ABL1 (0.86) | ABL1EGFRRAF1LYNBRAF | |
| SCHEMBL6546510 | 0.72 | MAPK14 (0.73) | ABL1EGFRRAF1LYNBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1438048-A1 | 1,4-DISUBSTITUTED BENZO-FUSED UREA COMPOUNDS AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-07-21 | — | — | EP | claimed |
| WO-2003032989-A1 | 1,4-DISUBSTITUTED BENZO-FUSED UREA COMPOUNDS AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-04-24 | — | — | WO | claimed |
| US-6825184-B2 | FOR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-11-30 | — | — | US | disclosed |