SCHEMBL6668460

SCHEMBL6668460

COc1cc(NC(=O)Nc2cccc(-c3c(Br)cnn3C)c2)ccc1Cl

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 20/20 0.74
HTR2C P28335 18/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6201624 0.85 HTR2A (1.00) HTR2AHTR2C
SCHEMBL6198081 0.84 HTR2A (0.80) HTR2AHTR2C
SCHEMBL6194881 0.83 HTR2A (0.77) HTR2AHTR2C
SCHEMBL6198546 0.83 HTR2A (0.73) HTR2AHTR2C
SCHEMBL6200979 0.81 HTR2A (0.63) HTR2AHTR2C
SCHEMBL6199703 0.80 HTR2A (0.78) HTR2AHTR2C
SCHEMBL5052896 0.80 HTR2A (1.00) HTR2AHTR2C
SCHEMBL29572799 0.80 HTR2A (1.00) HTR2AHTR2C
SCHEMBL6200102 0.80 HTR2A (0.59) HTR2AHTR2C
SCHEMBL6200786 0.79 HTR2A (0.77) HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004028450-A2 PROCESS OF MAKING PHENYLPYRAZOLES USEFUL AS SELECTIVE 5HT2A MODULATORS AND INTERMEDIATES THEREOF ARENA PHARMACEUTICALS, INC. (US) 2004-04-08 WO disclosed