Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.73 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.73 |
| ▸ | KDR | P35968 | 12/20 | 0.72 |
| ▸ | RET | P07949 | 9/20 | 0.72 |
| ▸ | KIF5B | P33176 | 7/20 | 0.72 |
| ▸ | EGFR | P00533 | 9/20 | 0.68 |
| ▸ | GAK | O14976 | 2/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.68 |
| ▸ | FLT1 | P17948 | 2/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | FLT3 | P36888 | 1/20 | 0.68 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.68 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.68 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.68 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.68 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.68 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864546 | 0.86 | KDR (0.82) | JAK3MKNK1KDRRETKIF5B | |
| SCHEMBL7119275 | 0.85 | JAK3 (0.74) | JAK3MKNK1KDRRETKIF5B | |
| SCHEMBL2100447 | 0.84 | KDR (0.80) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL22590721 | 0.84 | EGFR (0.80) | JAK3MKNK1KDRRETKIF5B | |
| SCHEMBL323445 | 0.84 | JAK3 (1.00) | JAK3MKNK1KDRRETKIF5B | |
| SCHEMBL5864555 | 0.84 | KDR (0.73) | JAK3MKNK1KDRRETKIF5B | |
| SCHEMBL30925305 | 0.84 | JAK3 (1.00) | JAK3MKNK1KDRRETKIF5B | |
| SCHEMBL7870579 | 0.84 | KDR (1.00) | JAK3MKNK1KDRRETKIF5B | |
| Hydrochloric Acid SCHEMBL7867185 | 0.83 | KDR (0.98) | JAK3KDRRETKIF5BEGFR | |
| SCHEMBL5477771 | 0.81 | KDR (1.00) | JAK3MKNK1KDRRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |
| US-6638939-B2 | Anticancer agents | PARKER HUGHES INSTITUTE | 2003-10-28 | — | — | US | disclosed |