Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.66 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 5/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.52 |
| ▸ | CD38 | P28907 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6666471 | 0.85 | EGFR (0.68) | EGFRERBB2 | |
| SCHEMBL5564480 | 0.83 | MAPK1 (0.76) | HTTKDM4EMAPK1NCOA1NCOA3 | |
| SCHEMBL5570037 | 0.82 | HTT (0.74) | HTTKDM4EMAPK1NCOA1NCOA3 | |
| SCHEMBL5569927 | 0.82 | KDM4E (0.74) | HTTKDM4EMAPK1NCOA1NCOA3 | |
| SCHEMBL5568874 | 0.82 | HTT (0.74) | HTTKDM4EMAPK1NCOA1NCOA3 | |
| SCHEMBL2101381 | 0.81 | HTT (1.00) | HTTKDM4EMAPK1NCOA1NCOA3 | |
| SCHEMBL5570080 | 0.80 | KDM4E (0.67) | HTTKDM4EMAPK1NCOA1NCOA3 | |
| SCHEMBL6663823 | 0.80 | ALK (0.74) | HTTMAPK1NCOA1NCOA3MAPT | |
| SCHEMBL15503743 | 0.80 | NCOA1 (1.00) | HTTKDM4EMAPK1NCOA1NCOA3 | |
| SCHEMBL5570076 | 0.80 | HTT (0.70) | HTTKDM4EMAPK1NCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |