Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL567444 | 0.79 | EGFR (0.47) | KDM4EGLAHDAC1HDAC2ALDH1A1 | |
| SCHEMBL3069800 | 0.72 | KDM4E (1.00) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL30326993 | 0.72 | KDM4E (0.50) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL28857293 | 0.71 | KDM4E (0.95) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL3085667 | 0.69 | FLT3 (0.38) | KDM4ENPC1RAB9ACYP1A2TP53 | |
| Dipyridyl SCHEMBL722577 | 0.67 | KDM4E (0.93) | KDM4ENPC1RAB9AMAPTGLA | |
| Dipyridyl SCHEMBL3796795 | 0.67 | KDM4E (0.93) | KDM4ENPC1RAB9AMAPTGLA | |
| Dipyridyl SCHEMBL29467582 | 0.67 | KDM4E (0.93) | KDM4ENPC1RAB9AMAPTGLA | |
| Dipyridyl SCHEMBL721272 | 0.67 | KDM4E (0.93) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL146382 | 0.66 | KDM4E (0.75) | KDM4ENPC1RAB9AMAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185521-B1 | SUBSTITUTED 1-AZA-2-IMINO-HETEROCYCLES AND THEIR USE AS ACTIVATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2004-10-06 | — | — | EP | disclosed |