Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.53 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10593732 | 0.92 | CYP24A1 (0.52) | CYP24A1CYP19A1CYP27A1CYP26A1DDB1 | |
| SCHEMBL15874767 | 0.92 | CYP24A1 (0.60) | CYP24A1CYP19A1CYP27A1CYP26A1DRD2 | |
| SCHEMBL3654990 | 0.92 | CYP24A1 (0.48) | CYP24A1CYP19A1CYP27A1CYP26A1DDB1 | |
| SCHEMBL13885522 | 0.92 | CYP24A1 (0.48) | CYP24A1CYP19A1CYP27A1CYP26A1DDB1 | |
| SCHEMBL4366122 | 0.92 | CYP24A1 (0.60) | CYP24A1CYP19A1CYP27A1CYP26A1DRD2 | |
| SCHEMBL10594987 | 0.90 | DDB1 (0.48) | CYP24A1CYP19A1CYP27A1CYP26A1DDB1 | |
| SCHEMBL3119314 | 0.90 | CYP24A1 (0.47) | CYP24A1CYP19A1CYP27A1CYP26A1DDB1 | |
| SCHEMBL22628673 | 0.90 | CYP24A1 (0.47) | CYP24A1CYP19A1CYP27A1CYP26A1DDB1 | |
| SCHEMBL10597721 | 0.90 | CYP24A1 (0.47) | CYP24A1CYP19A1CYP27A1CYP26A1 | |
| SCHEMBL10596034 | 0.88 | CYP24A1 (0.52) | CYP24A1CYP19A1CYP27A1CYP26A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0838459-B1 | Naphthyl compounds, compositions, and methods | LILLY CO ELI (US) | 2004-09-22 | — | — | EP | disclosed |
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5998401-A | POSTMENOPAUSE THERAPY | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| US-5952350-A | INHIBITING BONE LOSS OR BONE RESORPTION, PARTICULARLY OSTEOPOROSIS, AND CARDIOVASCULAR DISORDERS INCLUDING HYPERLIPIDEMIA, AND ESTROGEN DEPENDENT CANCER | ELI LILLY AND COMPANY (US) | 1999-09-14 | — | — | US | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0838459-A1 | Naphthyl compounds, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-29 | — | — | EP | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5021414-A | Antiestrogen | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-06-04 | — | — | US | disclosed |
| EP-0394194-A1 | Protected amino-acids and process for their preparation | CALBIOCHEM-NOVABIOCHEM AG (CH) | 1990-10-24 | — | — | EP | disclosed |
| US-4910212-A | Containing 1,2,4-triazole or imidazole ring | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-03-20 | — | — | US | disclosed |
| US-4904661-A | ANTIESTROGENS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-02-27 | — | — | US | disclosed |
| US-4833135-A | Antioestrogenic phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-23 | — | — | US | disclosed |
| EP-0281283-A1 | Heterocyclic compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-09-07 | — | — | EP | disclosed |
| US-4732912-A | ANTIESTROGENS, ANTITUMOR AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-03-22 | — | — | US | disclosed |
| EP-0124369-B1 | PHENOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-06-24 | — | — | EP | disclosed |
| EP-0166509-A1 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-02 | — | — | EP | disclosed |
| EP-0124369-A1 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-11-07 | — | — | EP | disclosed |