Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 8/20 | 0.57 |
| ▸ | FNTB | P49356 | 8/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874276 | 1.00 | FNTA (0.57) | FNTAFNTBTDP1PGGT1BKMT2A | |
| SCHEMBL6651028 | 0.93 | FNTA (0.61) | FNTAFNTBTDP1PGGT1B | |
| SCHEMBL6651023 | 0.93 | FNTA (0.61) | FNTAFNTBTDP1PGGT1B | |
| SCHEMBL6774366 | 0.85 | FNTA (0.57) | FNTAFNTBTDP1PGGT1BKMT2A | |
| SCHEMBL6774365 | 0.85 | FNTA (0.57) | FNTAFNTBTDP1PGGT1BKMT2A | |
| SCHEMBL6627431 | 0.85 | FNTA (0.58) | FNTAFNTBTDP1PGGT1BKMT2A | |
| SCHEMBL6627428 | 0.85 | FNTA (0.58) | FNTAFNTBTDP1PGGT1BKMT2A | |
| SCHEMBL6778825 | 0.79 | FNTA (0.50) | FNTAFNTBTDP1PGGT1BKMT2A | |
| SCHEMBL6778822 | 0.79 | FNTA (0.50) | FNTAFNTBTDP1PGGT1BKMT2A | |
| SCHEMBL7605763 | 0.78 | FNTA (0.58) | FNTAFNTBTDP1PGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986384-A4 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2004-09-15 | — | — | EP | disclosed |
| US-6310095-B1 | INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE | UNIVERSITY OF PITTSBURGH | 2001-10-30 | — | — | US | disclosed |
| EP-0986384-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998050029-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |