Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.57 |
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6043858 | 0.85 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL6574714 | 0.80 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL13930233 | 0.80 | BACE1 (0.57) | BACE1BACE2CTSD | |
| SCHEMBL13930108 | 0.79 | BACE1 (0.61) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL6681794 | 0.79 | BACE1 (0.55) | BACE1BACE2CTSD | |
| SCHEMBL13929735 | 0.79 | BACE1 (0.59) | BACE1BACE2CTSD | |
| SCHEMBL6043864 | 0.78 | BACE1 (0.56) | BACE1BACE2CTSD | |
| SCHEMBL8365141 | 0.78 | BACE1 (0.81) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL6294179 | 0.78 | BACE1 (0.55) | BACE1BACE2CTSD | |
| SCHEMBL5363946 | 0.78 | BACE1 (0.74) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458745-A2 | SUBSTITUTED AMINO CARBOXAMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003057721-A2 | SUBSTITUTED AMINO CARBOXAMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-07-17 | — | — | WO | disclosed |