Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 12/20 | 0.44 |
| ▸ | APOB | P04114 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674749 | 0.90 | MTTP (0.44) | MTTPAPOBGAASMN1; SMN2KDM4E | |
| SCHEMBL6678457 | 0.90 | MTTP (0.46) | MTTPAPOBGAASMN1; SMN2KDM4E | |
| SCHEMBL7035887 | 0.89 | MTTP (0.46) | MTTPAPOBGAASMN1; SMN2KDM4E | |
| SCHEMBL7253261 | 0.89 | MTTP (0.43) | MTTPAPOBGAASMN1; SMN2KDM4E | |
| SCHEMBL6678817 | 0.88 | MTTP (0.45) | MTTPAPOBGAASMN1; SMN2KDM4E | |
| SCHEMBL6674626 | 0.86 | MTTP (0.43) | MTTPAPOBGAASMN1; SMN2KDM4E | |
| SCHEMBL6685186 | 0.85 | MTTP (0.49) | MTTPAPOBGAA | |
| SCHEMBL7253319 | 0.85 | MTTP (0.50) | MTTPAPOBGAASMN1; SMN2KDM4E | |
| SCHEMBL6680330 | 0.84 | MTTP (0.49) | MTTPAPOBKDM4E | |
| SCHEMBL7256228 | 0.84 | MTTP (0.49) | MTTPAPOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465613-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | claimed |
| WO-2003057205-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | claimed |
| EP-1465613-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057205-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |