Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mafenide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mafenide SCHEMBL6673088 | 1.00 | FNTA (0.66) | FNTAFNTB | |
| Mafenide SCHEMBL7862561 | 0.99 | FNTA (0.66) | FNTAFNTB | |
| Mafenide SCHEMBL7862566 | 0.99 | FNTA (0.66) | FNTAFNTB | |
| P-Toluenesulfonamide SCHEMBL6645570 | 0.96 | FNTA (0.66) | FNTAFNTB | |
| P-Toluenesulfonamide SCHEMBL6645582 | 0.96 | FNTA (0.66) | FNTAFNTB | |
| P-Toluenesulfonamide SCHEMBL7870353 | 0.95 | FNTA (0.66) | FNTAFNTB | |
| P-Toluenesulfonamide SCHEMBL7870326 | 0.95 | FNTA (0.66) | FNTAFNTB | |
| SCHEMBL7869184 | 0.92 | FNTA (0.69) | FNTAFNTB | |
| SCHEMBL7869178 | 0.92 | FNTA (0.69) | FNTAFNTB | |
| SCHEMBL6626881 | 0.92 | FNTA (0.77) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986384-A4 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2004-09-15 | — | — | EP | claimed |
| EP-0986384-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 2000-03-22 | — | — | EP | claimed |