Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.43 |
| ▸ | USP19 | O94966 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4871797 | 1.00 | GSK3B (0.43) | GSK3BUSP19CYP1A2CYP2D6CDC7 | |
| SCHEMBL6673105 | 1.00 | GSK3B (0.43) | GSK3BUSP19CYP1A2CYP2D6CDC7 | |
| SCHEMBL4871806 | 1.00 | GSK3B (0.43) | GSK3BUSP19CYP1A2CYP2D6CDC7 | |
| SCHEMBL4872254 | 1.00 | GSK3B (0.43) | GSK3BUSP19CYP1A2CYP2D6CDC7 | |
| SCHEMBL4871119 | 0.90 | GSK3B (0.51) | GSK3BUSP19CYP1A2CYP2D6CDC7 | |
| SCHEMBL4871122 | 0.90 | GSK3B (0.51) | GSK3BUSP19CYP1A2CYP2D6CDC7 | |
| SCHEMBL4871116 | 0.90 | GSK3B (0.51) | GSK3BUSP19CYP1A2CYP2D6CDC7 | |
| Hydrochloric Acid SCHEMBL4865765 | 0.89 | GSK3B (0.50) | GSK3BUSP19CYP1A2CYP2D6CDC7 | |
| Hydrochloric Acid SCHEMBL4865769 | 0.89 | GSK3B (0.50) | GSK3BUSP19CYP1A2CYP2D6CDC7 | |
| Hydrochloric Acid SCHEMBL4865758 | 0.89 | GSK3B (0.50) | GSK3BUSP19CYP1A2CYP2D6CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430057-A2 | SUBSTITUTED 2-PYRIDINYL-6,7,8,9-TETRAHYDROPYRIMIDO 1,2-A]PYRIMIDIN-4-ONE AND 7-PYRIDINYL-2,3-DIHYDROIMIDAZO 1,2-A]PYRIMIDIN-5(1H)ONE DERIVATIVES | Sanofi-Aventis (FR) | 2004-06-23 | — | — | EP | claimed |
| WO-2003027116-A2 | SUBSTITUTED 2-PYRIDINYL-6,7,8,9-TETRAHYDROPYRIMIDO[1,2-A]PYRIMIDIN-4-ONE AND 7-PYRIDINYL-2,3-DIHYDROIMIDAZO[1,2-A]PYRIMIDIN-5(1H)ONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2003-04-03 | — | — | WO | claimed |