Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 16/20 | 0.59 |
| ▸ | CTSD | P07339 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8367140 | 0.85 | BACE1 (0.80) | BACE1BACE2 | |
| Hydrochloric Acid SCHEMBL6295174 | 0.84 | BACE1 (0.79) | BACE1BACE2 | |
| SCHEMBL6295287 | 0.82 | BACE1 (0.62) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL6294176 | 0.81 | BACE1 (0.61) | BACE1BACE2CTSD | |
| SCHEMBL6294127 | 0.81 | BACE1 (0.71) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL6295175 | 0.78 | BACE1 (0.55) | BACE1BACE2CTSD | |
| SCHEMBL3903017 | 0.78 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL3350112 | 0.76 | BACE1 (0.72) | BACE1BACE2CTSD | |
| SCHEMBL3357607 | 0.76 | BACE1 (0.72) | BACE1BACE2CTSD | |
| SCHEMBL6294154 | 0.74 | BACE1 (0.66) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458745-A2 | SUBSTITUTED AMINO CARBOXAMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-09-22 | — | — | EP | claimed |
| WO-2003057721-A2 | SUBSTITUTED AMINO CARBOXAMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-07-17 | — | — | WO | claimed |