Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28541 | 1.00 | HCAR2 (0.52) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL1126891 | 1.00 | HCAR2 (0.52) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL19125009 | 0.86 | HCAR2 (0.47) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL265410 | 0.86 | MAPT (0.50) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL15508254 | 0.86 | MAPT (0.50) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL14212858 | 0.86 | MAPT (0.50) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL29142926 | 0.85 | MAPT (0.46) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL4195651 | 0.84 | MAPT (0.49) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL3113307 | 0.84 | MAPT (0.49) | HCAR2MAPTALDH1A1TTRDPP4 | |
| SCHEMBL3113308 | 0.84 | MAPT (0.49) | HCAR2MAPTALDH1A1TTRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160355542-A1 | UNIVERSAL METHYLATION PROFILING METHODS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-12-08 | — | — | US | disclosed |
| EP-1112253-B1 | BRANCHED ALKYL PYRROLIDINE-3-CARBOXYLIC ACIDS | WARNER LAMBERT CO (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1112253-A1 | BRANCHED ALKYL PYRROLIDINE-3-CARBOXYLIC ACIDS | WARNER-LAMBERT COMPANY (US) | 2001-07-04 | — | — | EP | disclosed |
| US-6245801-B1 | ANTIEPILEPIC AGENTS; BRAIN DISORDERS; PSYCHOLOGICLA DISORDERS | WARNER-LAMBERT COMPANY | 2001-06-12 | — | — | US | disclosed |
| WO-2000015611-A1 | BRANCHED ALKYL PYRROLIDINE-3-CARBOXYLIC ACIDS | WARNER-LAMBERT COMPANY (US) | 2000-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355542-A1 | UNIVERSAL METHYLATION PROFILING METHODS | DNMT1, DNMT3A, DNMT3B | HCAR2 3853/4885MAPT 3925/4885ALDH1A1 1498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.